HEV(Rapid)

Hepatitis E (Hepatitis E) is an acute infectious disease transmitted by feces. Since the first outbreak of hepatitis E occurred in India in 1955 due to water pollution, it has been prevalent in India, Nepal, Sudan, Kyrgyzstan of the Soviet Union, Xinjiang and other places in China.

HEV is discharged with patients’ feces, spread through daily life contact, and can be distributed or outbreak epidemic caused by contaminated food and water sources. The peak of incidence is usually in the rainy season or after floods. The incubation period is 2~11 weeks, with an average of 6 weeks. Most of the clinical patients are mild to moderate hepatitis, often self limiting, and do not develop into chronic HEV. It mainly invades young adults, more than 65% of which occur in the age group of 16 to 19 years old, and children have more subclinical infections.

The case fatality rate of adults is higher than that of hepatitis A, especially for pregnant women who suffer from hepatitis E, and the case fatality rate of infection in the last three months of pregnancy is 20%.
After HEV infection, it can produce immune protection to prevent HEV reinfection of the same strain or even different strains. It has been reported that anti HEV antibody in serum of most patients after rehabilitation lasts for 4-14 years.
For experimental diagnosis, virus particles can be found from feces by electron microscope, HEV RNA in fecal bile can be detected by RT-PCR, and anti HEV IgM and IgG antibodies in serum can be detected by ELISA using recombinant HEV glutathione S-transferase fusion protein as antigen.
The general prevention of hepatitis E is the same as that of hepatitis B. Common immunoglobulins are ineffective for emergency passive immunization.